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ClC-3在人肺癌中的表达及分布 被引量：1

Expression and distribution of CIC-3 in human pulmonary carcinoma
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摘要 目的:探讨ClC-3在人肺癌组织中的表达及其生物学意义.方法:应用免疫组织化学染色技术检测76例人肺癌标本中ClC-3蛋白的表达.结果:76例人肺癌标本中阳性表达69例(90.8%),对照组10例正常肺组织ClC-3蛋白的表达为阴性;而蛋白表达阳性的69例肺癌中,ClC-3主要位于瘤细胞和微血管内皮细胞的胞浆内或细胞膜上.随着TNM分期升级,ClC-3蛋白表达也呈逐渐上调趋势(P<0.01).结论:ClC-3在人肺癌及肺转移癌组织中普遍表达,并且可能与肺癌TNM分期相关. AIM： To investigate the expression and biological significance of CIC-3 in pulmonary carcinoma. METHODS： The expression of CIC-3 in pulmonary carcinoma samples from 76 patients with lung cancer was detected by immunohistochemistry. RESULTS： There were 69 samples （90. 8%） with positive response in 76 lung cancer samples. No sample was positive in normal control group（n = 10）. CIC-3 was mainly located in the membrance and plasma of oncocytes and capillary endothelial cells. The expression of CIC-3 rose as TNM stage of cancer stepped up. CONCLUSION： CIC-3 expresses commonly in pulmonary carcinoma and its metastasis, which may be related to TNM staging.
作者 王丙清 宋立强 吴昌归
机构地区 第四军医大学西京医院呼吸内科
出处 《第四军医大学学报》 北大核心 2007年第16期1509-1511,共3页 Journal of the Fourth Military Medical University
关键词 肺癌 蛋白质ClC-3 免疫化学 氯化物通道 pulmonary carcinoma CIC-3 protein immunohisto- chemistry chloride channel
分类号 R734.2 [医药卫生—肿瘤]
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参考文献7

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共引文献23

同被引文献12

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第四军医大学学报
2007年 第16期

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