儿童Tourette综合征患者执行功能的研究

Study of executive functions in children with Tourette's syndrome

目的探讨儿童Tourette综合征患者执行功能的特征。方法采用视觉记忆测验、流畅性测验、字色干扰测验、威斯康星卡片分类测验,分别测试53例Tourette综合征患儿和51名正常儿童的工作记忆、注意抑制、认知灵活性、计划性和定势转移能力等多项执行功能,并进行比较。结果Tourette综合征患儿在即时和延迟图形记忆、3项流畅性测验、字色干扰测验、威斯康星卡片分类测验中的成绩均明显低于正常儿童(均P<0.01)。结论Tourette综合征患儿的工作记忆能力下降,在持续性注意和反应抑制、认知灵活性、思维组织性、计划性和定势转移等能力方面存在障碍。

Objective To investigate the features of executive functions （EFs） of children with Tourette＇s syndrome （TS）. Methods Several EFs such as working memory, attention and inhibition, flexibility, planning and diversion were measured in TS group （53 child patients） and control group （51 healthy children） with the Visual Figure Memory Tests, Fluency Tests, Stroop Tests （ C and CW）, Wisconsin Card Sorting Test （WCST）. Results Compared to control group, the patients with TS had significant poor executive performances in Visual Figure Memory Tests, Fluency Tests, Stroop Tests and WCST （all P 〈 0.01 ）. Conclusions The ability of visual and verbal working memory declines in the patients with TS, and the patients have difficulty in sustained attention and response inhibition, cognitive flexibility, thought organization and diversion.