多药耐药蛋白和CYP3A4介导的中草药-西药相互作用

MDR-and CYP3A4-mediated drug-herbal interactions

据近年的流行病学报告,国内外越来越多的人终身服用各种中草药,包括各类疾病患者(如:癌症等)和健康人群。随着中草药与处方西药联合应用治疗疾病的日益增多,越来越多的人注意到这两者的同时使用可能引起的中草药-西药相互作用会影响到治疗药物的活性。目前已知P-糖蛋白(P-gp)和CYP3A4一起能构成许多口服吸收药物的高效屏障,然而50%以上的临床用药都会被CYP3A4代谢或被P-gp转运。本文综述了多药耐药蛋白和CYP3A4介导的中草药-西药相互作用,同时也讨论了中草药-西药相互作用的关键因素。

According to recent epidemiological reports more and more people, both healthy and ill, use all kinds of Chinese herbal medicine during their lifetime. As the increasing combined usage of Chinese herbal medicine with prescription drags, it draws lots of attentions on the therapeutic activity due to possible drug-herb interaction. It is known that P-glycoprotein （P-gp） together with cytochrome P450 3A4 （CYP3A4） leads to a highly efficient barrier for many orally absorbed drugs. Meanwhile, more than 50% of the clinical drugs are metabolized by CYP3A4 or transported by P-gp. Hence, more attention should be paid to MDR-and CYP3A4-mediated drug-herbal interactions. This survey discusses the key-factors of drug-herbal interaction as well.