长期低剂量阿奇霉素治疗儿童慢性分泌性中耳炎

Clinical observation of long-term treatment with low-dose azithromycin in otitis media with effusion in children

目的观察阿奇霉素治疗儿童慢性分泌性中耳炎的疗效。方法将35例(60耳)患儿分为阿奇霉素组(18例,31耳)与对照组(17例,29耳),两组患者同时给0.5%麻黄碱滴鼻,波氏球咽鼓管吹张2周,阿奇霉素组同时口服阿奇霉素10mg/kg,开始3天每天1次,以后每周2次,疗程为8周;对照组口服阿莫西林,25mg/kg,3次/日,疗程为2周。8周后对比观察两组的治疗效果。结果阿奇霉素组的治疗有效愈率为80.64%,显著高于对照组44.83%(P<0.01);治疗后阿奇霉素组听阈为(18.55±4.52)dB,显著好于对照组[(27.48±7.27)dB,P<0.01]。结论长期低剂量口服阿奇霉素治疗儿童慢性分泌性中耳炎效果较好。

OBJECTIVE To study the effect of long term treatment with low-dose azithromycin on otitis media with effusion in children. METHODS Thirty-five children （60 ears） with otitis media with effusion were divided into two groups, azithromycin group（18 cases, 31 ears） and control group（17 cases, 29 ears）. Ephedrine solution for nasal application was used for 2 weeks. Azithromycin group received 10 mg/kg of azithromycin daily for 3 days, and then 2 times per week for 8 weeks. Control group received 25 mg/kg of Amoxicillin, 3 times a day for 2 weeks. Clinical responses were assessed at the end of treatment. RESULTS The cure rate of the azithromycin group （80.64 %） was much higher than that in control group （44.83%, P〈0.01）. The auditory threshold of the azithromycin group is （18.55±4.52） dB, which is significant lower than that in control group （27.48±7.27） dB （P〈0.01）. CONCLUSION Long term treatment with low-dose azithromycin is a reliable and effective method for otitis media with effusion in children.