摘要
目的探讨儿童肥大腺样体T淋巴细胞亚群免疫失衡与反复发作性分泌性中耳炎的关系。方法106例分泌性中耳炎患儿腺样体组织(72例中耳炎发作次数大于3次,34例中耳炎发作次数少于等于3次)及30例单纯腺样体肥大患儿腺样体组织。采用免疫组化方法检测上述各组T淋巴细胞CD4+、CD8+的表达及CD4+/CD8+值,统计分析三组之间是否有差别。结果反复发作性分泌性中耳炎(中耳炎发作次数大于3次)患儿腺样体组织中CD4+、CD8+细胞数及CD4+/CD8+分别为41.9±9.07,20.45±7.08,2.10±0.17;较非反复发作性分泌性中耳炎组(中耳炎发作次数少于等于3次)17.4±6.85,13.02±5.88,1.33±0.11及单纯腺样体肥大组(无中耳炎病史)16.3±8.21,11.15±5.71,1.39±0.15均有显著性差异(P<0.05);其中CD4+细胞数明显多于CD8+细胞数;非反复发作性分泌性中耳炎组患儿腺样体组织中CD4+、CD8+的表达及CD4+/CD8+与单纯腺样体肥大组比较无明显差异(P>0.05)。结论反复发作性分泌性中耳炎的形成与T淋巴细胞亚群免疫失衡有关。
OBJECTIVE To investigate the relationship of immunity imbalance of T-lymphocyte subsets and recurrent SOM. METHODS The adenoid tissue samples of 106 children with secretory otitis media （of which, 72 cases were recurrent more than 3 times and 34 cases were recurrent less than or equal to 3 times） and adenoid tissue samples of 30 children with adenoid hypertrophy without SOM were studied by immunohistochemical method. RESULTS There were more CD4^＋ and CD8^＋ cells in adenoid tissue samples in patients with recurrent SOM （SOM recurrent more than 3 times ）. The CD4^＋, CD8^＋ cells and CD47CD8^＋ in adenoid tissue samples in patients with recurrent SOM were 41.9±9.07, 20.45±7.08 and 2.10± 0.17 respectively, which were significantly different compared with that in patients with recurrent SOM less than or equal to 3 times （17.4±6.85, 13.02± 5.88, 1.33 ±0.11 respectively） and in patients without SOM （16.3±8.21, 11.15±5.71 and 1.39±0.15 respectively） （P〈0.05）; The CD4^＋ cells was obviously high. There was no significant difference between CD4^＋ , CD8^＋ and CD47CD8^＋ in patients with recurrent SOM less than or equal to 3 times and patients without SOM. CONCLUSION SOM is relative to the immunity imbalance of T-lymphocyte.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2007年第8期463-465,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
