莫索尼定降压及逆转左室肥厚的临床效果观察

Clinical observation on hypotensive and left ventricular hypertrophy-reversing effects by moxonidine

目的探讨莫索尼定降压效果和逆转患者左室肥厚的作用。方法将80例高血压合并左室肥厚患者分为莫索尼定(治疗)组和卡托普利(对照)组治疗,观察6个月,比较两组血压(BP)和左心室肥厚的变化。结果莫索尼定治疗使BP从(163.5/80.7±16.7/10.5)mmHg降至(125.7/71.3±13.6/8.53)mmHg(P<0.05),左心室质量指数(LVMI)从(145.8±13.0)g/m2降至(122.3±11.8)g/m2(P<0.05),但治疗组的BP和LVMI变化与对照组之间比较无差异。结论莫索尼定具有显著降压作用,长期使用能够显著逆转左心室肥厚。

Objective To investigate the hypotensive effect and the reversion of left ventricular hypertrophy by moxonidine. Methods A total 80 hypertensive patients with left ventricular hypertrophy （ LVH ） were divided into the groups of moxonidine and captopril. The changes of blood pressure （ BP） and LVH between groups were compared after 6 months. Results After treatment by moxonidine, BP was decreased from （ 163. 5/80. 7 ± 16. 7/10. 5 ） mmHg to （ 125.7/71.3 ± 13.6/8.53 ） mm- Hg （P 〈 0. 05）, and the left ventricular myocardial mass index （LVMI） from （145.8± 13, 0） g/m^2 to （122. 3± 11.8） g/m^2 （ P 〈 0. 05）. But the changes between two groups were not significant different. Conclusion Moxonidine possesses a potent hypotensive effect and can substantially reverse LVH after a long-time usage.