胃肠道间质瘤的临床病理学分析

Clinicopathological analysis of gastrointestinal stromai tumor

目的探讨胃肠道间质瘤临床病理学特点。方法回顾性分析四川省人民医院1998年1月至2005年12月间98例胃肠道间质瘤的临床病理资料。结果本组胃肠道间质瘤中胃60例，小肠15例，结直肠12例，食管2例，网膜和肠系膜9例，肿瘤最大直径为2．8—15．0cm。免疫组织化学检查：CD117阳性率为100％，CD34阳性率为88％，S-100阳性率为29％，α-SMA阳性率为45％。2年生存率为87％。结论CD117、CD34等免疫标志物是胃肠道间质瘤诊断最有价值的指标。外科手术和术后应用甲磺酸伊马替尼化学治疗是有效的胃肠道间质瘤综合治疗方法。

Objective To investigate the clinicopathological features of gastrointestinal stromal tumor. Methods We analyze retrospectively the data of 98 consecutive patients with gastrointestinal stromal tumor undergoing surgery and postoperative chemotherapy. Results Tumor size was between 2. 8 cm and 15.0 cm. Tumor was in the stomach in 60 cases,in the small bowel in 15, in the colorectum in 12, in the esophagus in 2 and in the omenta and mesenterium in 9. Immunohistochemically, CDll7 and CD34 was positive in 100% and 88% respectively. S-100, α-SMA was positive in 29%, and 45% respectively. The overall 2-year survival rate is 87%. Conclusion CDll7 and CD34 are the most valuable tumor markers in diagnosing gastrointestinal stromal tumor. Surgical resection and imatinib mesylate based chemotherapy are effective for gastrointestinal stromal tumor.