结肠癌及癌前病变组织中COX-2及VEGF的表达

Expression of Cyclooxygenase-2 and Vascular endothelial growth factor in precancerous lesions and colon carcinoma tissue

目的:探讨结肠癌及癌前病变中COX-2和血管内皮生长因子(VEGF)的表达意义.方法:应用免疫组织化学ABC法检测COX-2及VEGF在40例癌旁正常结肠黏膜和结肠癌、27例结肠腺瘤组织中COX-2和VEGF的表达.结果:结肠腺瘤和结肠癌组COX-2阳性表达率明显高于癌旁正常结肠黏膜组(63.0%,77.5%vs0.0%,0.0%;P<0.05).结肠腺瘤和结肠癌组VEGF阳性表达率明显高于癌旁正常结肠黏膜组(70.4%,80.0%vs25.0%,25.0%;P<0.05),且二者表达有相关性(r=0.411,P<0.01).结论:COX-2和VEGF在结肠腺瘤及结肠癌中表达异常增高.

AIM： To determine the cIinicaI significance of expression of cyclooxygenase-2 （COX-2） and vascular endothelial growth factor （VEGF） in normal colon epithelium near colon carcinoma, and in precursors and colon carcinoma. METHODS： Immunohistochemistry （ABC） was utilized to detect the expression of COX-2 and VEGF in 40 normal colon epithelium, 27 adenomatous polyposis of the colon, and 40 colon carcinoma tissues. RESULTS： Immunoreactivity of COX-2 and VEGF in adenomatous polyposis of the colon and colon carcinoma was much higher than that in normal tissues （COX-2, 63.0 and 77.5% vs 0.0 and 0.0%; VEGF, 70.4 and 80.0% vs 25.0 and 25.0%, respectively; P 〈 0.05）. The relationship between COX-2 and VEGF was statistically significant （r =0.411, P 〈 0.05）. CONCLUSION： COX-2 and VEGF expression is up-regulated in adenomatous polyposis of the colon and colon carcinoma.