直肠癌中MIC-1,VEGF和P53表达的临床意义

Expression of macrophage inhibitory cytokine-1, vascular endothelial growth factor and P53 and its clinical significance in rectal cancer

目的:探讨直肠癌中巨噬细胞抑制因子-1(MIC-1),血管内皮生长因子(VEGF),P53基因蛋白表达与病理特征的相关性.方法:用免疫组化法检测73例直肠癌中MIC-1,VEGF和P53的表达,并与临床病理因素进行相关性分析.结果:MIC-1,VEGF,P53表达均与直肠癌临床分期显著相关(χ2MIC-1=37.534,χ2VEGF=54.451,χ2P53=16.834;P<0.01);三者联合阳性表达率与临床分期呈显著线性相关(r=0.918,P=0.000).MIC-1表达与VEGF,P53表达呈正相关(r=0.808,r=0.369,P<0.01).结论:MIC-1,VEGF,P53在直肠癌发生、发展中呈协同和相互调节作用,联合检测他们的阳性表达有助于直肠癌侵润转移的判断.

AIM： To investigate the expression of macrophage inhibitory cytokine-1 （MIC-1）, vascular endothelial growth factor （VEGF） and P53 in rectal cancer, and its relationship to clinicopathological parameters. METHODS： Expression of MIC-1, VEGF and P53 in 73 cases of rectal cancer was assessed by immunohistochemistry, and its correlation with clinicopathological factors was statistically analyzed. RESULTS： Expression of MIC-1, VEGF and P53 had a significant correlation with clinical stage （χ^2 MIC-1 = 37,534,χ^2VEGF = 54.451, χ^2p53 = 16.834, respectively; P 〈 0.01）. There was a significant linear relationship between the levels of the three oncoproteins and clinical stage in patients with rectal cancer （r = 0.918, P = 0.000）. The ex-pression of MIC-1 also had a positive correlation with the expression of VEGF and P53 （r = 0.808, r = 0.369, respectively; P 〈 0.01）. CONCLUSION： MIC-1, VEGF and P53 have synergetic and mutual regulation in the occurrence and development of rectal cancer. The combined detection of their expression may help to determine progression and metastasis in rectal cancer.