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脑梗死患者ICAM-1基因K469E及IL-6基因-174G/C多态性研究 被引量：6

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摘要 目的探讨脑梗死与细胞间黏附分子-Ⅰ(ICAM-1)基因K469E多态性及白介素-6(IL-6)基因-174G/C多态性的相关性。方法运用多聚酶链式反应技术(PCR)检测177例脑梗死患者及112例对照者ICAM-1基因K469E多态性及IL-6基因-174G/C多态性各等位基因频率。结果脑梗死患者ICAM-1基因的K469E多态性与对照组比较,KK纯合子频率显著低于对照组(40.7%vs55.4%,P=0.015),KE杂合子频率显著高于对照组(48.6%vs35.7%,P=0.032),E等位基因频率亦显著高于对照组(35.0%vs26.8%,P=0.038),KE和EE基因型与KK基因型的比值比为1.808(95%CI,1.121～2.917)。脑梗死患者组和对照组IL-6基因-174G/C多态性均为GG型纯合子,未检测出C等位基因。结论ICAM-1基因K469E多态性的E等位基因携带者可能患脑梗死的风险增加。
作者 尤劲松 黄培新 刘茂才 黄燕
机构地区 广东省中医药大学第二附属医院神经内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第16期1580-1582,共3页 Chinese Journal of Gerontology
关键词 脑梗死 细胞间黏附分子-Ⅰ 白介素-6
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献14

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二级参考文献10

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共引文献33028

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二级引证文献19

中国老年学杂志
2007年 第16期

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