大黄醇提液抗家兔实验性高脂血症及脂肪肝的实验研究

THE EFFECT OF RHUBARB ETHANOL-EXTRACT ON HYPERLIPIDEMIA AND LIVER FATTY IN RABBITS

目的:检验大黄醇提液抗家兔实验性高脂血症及脂肪肝的影响。方法:将30只雄性健康白兔随机分为5组(n=6):对照组给予基础饲料;模型组给予高脂饲料;三个大黄组给予高脂饲料同时分别灌胃不同药量的大黄醇提液。实验过程中进行一般性指标观测,检测不同阶段五组家兔血脂水平,检测脂肪肝病变程度。结果:大黄醇提液具有降低血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C),升高高密度脂蛋白胆固醇(HDL-C),降低肝细胞脂肪变性的作用。并且大黄醇提液的以上作用存在一定的量效关系。结论:大黄醇提液可降低动脉粥样硬化兔模型的血脂水平、降低脂肪肝的发生发展。

Aim：To observe the effect of rhubarb ethanol-extract on hyperlipidemia and liver fatty in rabbits.Methods：Thirty healthy male white rabbits were divided randomly into five groups,six rabbits in each group.The rabbits in control group were fed with common forage.The rabbits in model group were fed with high lipid forage.The rabbits in three different rhubarb groups were fed with high lipid forage and treated with different level rhubarb ethanol-extract（REE）.In the process of experiment,periodically measured sero-logy index of the rabbits and observed common physiology index.The rabbits were killed at the end of tenth week,liver fatty degeneration degree and liver coefficient were measured and compared.Results：REE could decrease serum total cholesterol（TC）and low density lipoprotein cholesterol（LDL-C）,and increase serum high density lipoprotein cholesterol（HDL-C）,and reduce liver fatty degeneration and protect liver cell function.And the dose-effect relation was showed among different dose REE groups.Conclusion：REE can significantly reduce blood lipid,prevent and treat hyperlipidemia and liver fatty.