摘要
目的:建立高效液相色谱法测定氯沙坦钾片含量,为质量控制提供有效的分析手段。方法:色谱柱:Phenomenex ODS C18(5μm、4.6mm×150mm);流动相:乙腈-0.1%磷酸溶液(55:45);检测波长:230nm。结果:制剂中辅料和有关物质对主药无干扰,氯沙坦钾在浓度100.2～350.8μg/mL范围内线性关系良好,相关系数r=0.9999;平均回收率分别为99.36%、99.68%、99.40%,RSD为0.42%。结论:本法专属性好,准确,简便。
Objective：In order to control the quality of Losartan potassium tablets by high performance liquid chromatography for the determination of Losartan potassium tablets. Methods：The chromatographic column of phenomenex ODS C18 （5μm, 4. 6mm ×150mm） was used. The mobile phase consisted of acetonitrile-0.3% phosphoric acid solution （55：45）. The detection wavelength was at 230nm. Results ： Alfuzosin and the other components in the samples were completely separated. The relationship between response and the concentration in the range of 100. 2- 350. 8μg/mL was Linear with the correlation coefficient of 0. 9999. The average recovery was 99.36%,99.68% and 99. 40%, respectively , and RSD was 0.42%. Conclusion：The method is specific,accurate and simple.
出处
《黑龙江医药科学》
2007年第4期19-20,共2页
Heilongjiang Medicine and Pharmacy
关键词
高效液相色谱法
氯沙坦钾片
质量控制
high performance liquid chromatography
Losartan potassium tablets
quality control
