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TLR9与实验性自身免疫性脑脊髓炎 被引量：2

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摘要 Toll样受体9(toll-like receptor 9,TLR9)通过识别细菌和病毒DNA中未甲基化的胞嘧啶-磷酸-鸟嘌呤(CpG DNA)序列激活天然免疫应答和获得性免疫应答,从而促进宿主抵抗感染性疾病。但一定条件下,TLR9活化亦可促发某些自身免疫性疾病如实验性自身免疫性脑脊髓炎(EAE)。该文就TLR9的结构、配体、信号转导通路及TLR9在EAE中的作用机制进行综述。
作者 张勇 杨欢 肖波
机构地区 中南大学湘雅医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 2007年第5期272-275,共4页 Chinese Journal of Neuroimmunology and Neurology
关键词 To11样受体9 CPG DNA 实验性自身免疫性脑脊髓炎
分类号 R744.5 [医药卫生—神经病学与精神病学]
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  • 1Carbone FR, Heath WR. The role of dendritic cell subsets in immunity to viruses. Curt ODin Immunol 2003: 15:416-20.
  • 2Edwards AD, Chaussabel D, Tomlinson S, et al. Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns. J Immunol 2003; 171:47-60.
  • 3Fitzgerald KA, McWhirter SM, Faia KL, et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003; 4:491-6.
  • 4Sharma S, tenOever BR, Grandvaux N, et al. Triggering the Interferon Antiviral Response Through an IKK-Related Pathway.Science 2003: 300:1148-51.
  • 5Agalioti T, Lomvardas S, Parekh B, et al. Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter. Cell 2000; 103:667-78.
  • 6Erlandsson L, Blumenthal R, Eloranta M-L, et al. Interferon-β is required for interferon-ct production in mouse fibroblasts. Current Biology 1998; 8:223-6.
  • 7Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005;434:772-7.
  • 8Munshi N, Agalioti T, Lomvardas S, et al. Coordination of a Transcriptional Switch by HMGI(Y) Acetylation. Science 2001;293:1133-6.
  • 9Sato M, Suemori H, Hata N, et al. Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction. Immunity 2000; 13:539-48.
  • 10Lin R, Genin P, Mamane Y, Hiscott J. Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7. Mol Cell Biol 2000; 20:6342-53.

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同被引文献18

  • 1任涛,李传友,蔡映云,金美玲,胡芸文复旦大学医学分子病毒学教育部重点实验室,袁正宏复旦大学医学分子病毒学教育部重点实验室,田苗,赵冰.CpG寡脱氧核苷酸增强小鼠抗结核分枝杆菌感染的作用与机制[J].中华结核和呼吸杂志,2006,29(2):87-91. 被引量：6
  • 2Wilkinson J,Radkowski M,Laskus T,et al. Hepatitis C virus neuroinvasion= identification of infected cells [J]. J Virol, 2009,83(3) :1312 1319.
  • 3Bednarska A, Horban A,Rafkowski M. Central nervous sys tern as a possible site of HCV replication [J]. Przegl Epidemiol, 2007,61 (4) : 739-745.
  • 4Sharma A, Maheshwari RK. Oligonucleotide array analysis of Toll-like receptors and associated signalling genes in Venezue- lan equine encephalitis virus infected mouse brain[J].J Gen Virol,2009,90(10) :1836-1847.
  • 5Crack PJ, Bray PJ. Toll like receptors in the brain and their potential roles in neuropathology[J]. Immunol Cell Biol, 2007,85(6) :476-480.
  • 6Krieg AM. Antiinfective applications of Toll-like receptor 9 agonists[J]. Proc Am Thorac Soc,2007,4(3):289-294.
  • 7Krieg AM. Therapeutic potential of TolMike receptor 9 activa- tion[J]. Nat Rev Drug Discov, 2006,5 ( 5 ) : 471-484.
  • 8Booth JS, Buza JJ,Potter A,et al. Co stimulation with TLR7/ 8 and TLR9 agonists induce down-regulation of innate immune responses in sheep blood mononuclear and B cells [J].Dev Comp ImmLmol,2010,34(5) :572-578.
  • 9KristinLadell,MarcusDorner,LudwigZauner,ChristophBerger,FranziskaZucol,MicheleBernasconi,Felix K.Niggli,Roberto F.Speck,DavidNadal.Immune activation suppresses initiation of lytic Epstein‐Barr virus infection[J].Cellular Microbiology.2007(8)
  • 10贾妮娜,谢青,安宝燕,林兰意,沈怀成,王晖,周霞秋,俞红,郭清.慢性乙型肝炎病毒感染者外周血浆样树突状细胞Toll样受体9的表达和分泌功能[J].中华传染病杂志,2007,25(12):714-718. 被引量：4

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中国神经免疫学和神经病学杂志
2007年 第5期

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