鱼用新药“康达富”对鳗鲡弧菌和福建爱德华氏菌的杀灭作用

In vitro Bactericidal Action of a New Fish Drug “ Kangdafu ” against Vibrio and Edwardsiella fujianensis of the Eel, Anguilla japonica

用２倍稀释法测定了新药“康达富”对鳗鲡弧菌、鳗鲡福建爱德华氏菌的杀灭作用，结果表明，该药对鳗鲡弧菌、鳗鲡福建爱德华氏菌有极强的杀灭作用，其最低抑菌浓度分别为０．００４ｍｇ／ｍｌ和０．０００４ｍｇ／ｍｌ，最低杀菌浓度分别为０．００８ｍｇ／ｍｌ和０．０００８ｍｇ／ｍｌ。采用琼脂扩散纸片法，检测了“康达富”商品药的原药Ａ和原药Ｂ对鳗鲡福建爱德华氏菌的联合杀灭作用，结果表明，两种原药的杀灭效果呈显著的累加作用。

The in vitro bactericidal action of a new commercial fish drug “ Kangdafu ” against Vibrio and Edwardsiella fujianensis of the eel, Anguilla japonica, was determined by using the two fold dilution method. The results showed that the new fish drug “ Kangdafu ” had very strong bactericidal action against Vibrio and Edwardsiella fujianensis of the eel, Anguilla japonica, and the minimal inhibitory concentration ( MIC ) to the Vibrio and Edwardsiella fujianensis was 0.004 mg/ml and 0.0004 mg/ml respectively, the minimal bactericidal concentration ( MBC ) was 0.008 mg/ml and 0.0008 mg/ml respectively . The combined bactericidal action of drug “ A ” ingredient and drug “ B ” ingredient form which the commercial fish drug “ Kangdafu ” was prepared against the Edwardsiella fujianensis had been assayed by using the agar diffusion paper method. The result revealed that the drug “ A ” ingredient and drug “ B ” ingredient had significant accumulative bactericidal action.