孕妇携带乙肝病毒对产后母乳的影响

Study on the influnence of the pregnant carried HBV to mother milk

目的:探讨孕妇携带乙肝病毒(HBV)在产后母乳、新生儿血内HBV的携带情况。方法:符合研究标准的61例HBV携带的孕妇,分为两组。在妊娠28周、32周、36周各注射乙型肝炎免疫球蛋白(HBIC)200个国际单位,孕期接受治疗的31例产妇为研究组。未接受治疗的30例产妇为对照组。采用套式PCR方法。监测产后72h内母乳、新生儿血内HBV携带情况并对两组进行比较。结果:携带HBV61例中,研究组31例注射HBIC检测母乳HBV-DNA阳性的14例占45.16%(14/31),检测新生儿血HBV-DNA阴性,产生抗-HBsAg16例占51.61%(16/31);对照组30例未注射HBlC检测母乳HBV-DNA阳性的24例占(24/30),检测新生儿血HBV-DNA阴性,产生抗-HBsAg7例占23.33%(7/30);另有携带HBsAg2例占3.28%(2/30)。两组进行比较有统计学意义,P<0.05。结论:孕期HBV携带与母乳HBV携带关系密切。证明在孕期注射HBIC可以增加新生儿对HBV的免疫力,同时降低母乳、新生儿血中HBV含量。孕期没有进行HBIC治疗的新生儿对HBV免疫力较差。在孕期进行HBIC治疗是预防HBV母儿传播的有效措施。

Objective： To study the influnence of the pregnant carried HBV to mother milk. Methods： 61 pregnants carried HBV were divided into two groups. 31 pregnants who were injected HBIC at pregnant 28 week and 32 week and36 week each intramuscular were study group; Another 30 pregnants who were not injected HBIC at pregnant intramuscular were control group. HBV -DNA in mother milk and blood of newborn baby for two groups were ckecked by nested PCR respectively in the postpartum 72 hour. Results ： In study group, 14 （ 14/31 ） cases of HBV - DNA of mother milk were positive, 16 （ 16/31 ） cases of HBV - HbsAg of newborn baby blood were negative. In compare group, 24 （24/30） cases of HBV - DNA of mother milk were positive, and 7 （7/30） cases of HBV - HBsAg of newborn baby blood were negative. Conclusion ： The pregnant women blood of earring HBV , and the mother milk and newborn baby blood , this is question has a bearing on a much more important one. Injecting HBV for the pregnant women can add immunity to newborn baby and may prevent HBV.