南海红树林内生真菌ZZF42中生物碱类代谢产物的研究

Alkaloid Metabolites of Mangrove Endophytic Fungus ZZF42 from the South China Sea

从南海红树林内生真菌ZZF42的代谢产物中分离得到4种生物碱:Apicidin(1),N-methylharman(2),环苯丙-酪肽(3),吲哚-3-乙酸(4)。它们的结构通过波谱方法得到确定。化合物1为首次从该海洋真菌中分离发现,化合物2为首次从该海洋微生物中分离发现。药理实验结果表明,化合物1对人鼻咽癌细胞株KB和人鼻咽癌细胞耐药株KBv200的IC50均小于0.78μg/ml。

Four compounds, apicidin（ 1 ） , N-methylharman（ 2 ） , cylo （Phe-Tyr） （ 3 ） and indole-3-acetic acid （4） were isolated from the mangrove endophytic fungus ZZF42 from the South China Sea. Their structures were elucidated by spectral data. Compound 1 was first isolated from the marine fungus. Compound 2 was firstly isolated from marine microorganism. Compound 1 exhibited selective in vitro cytotoxicity towards KB and KBv200 with ICs0 values of less than 0. 78μg/ml.