脑肿瘤干细胞

Brain Tumor Stem Cells

脑肿瘤尤其是恶性脑胶质瘤,由于生长及复发快,预后极差,所以找到胶质瘤复发的根源,提高胶质瘤病人的存活率,已成为国内外的肿瘤生物学工作者和临床医学工作者亟待解决的难题。近年来肿瘤干细胞概念的提出及脑肿瘤干细胞的分离及鉴定,为脑肿瘤的研究提供了新的切入点,同时可成为肿瘤治疗新的靶标,为根治脑肿瘤带来了光明的前景。简要综述了脑肿瘤干细胞无限增殖、自我更新、多分化潜能的生物学特性,脑肿瘤干细胞的起源以及与脑肿瘤相关机制方面的研究进展,从而为今后脑肿瘤早期诊断、治疗以及以此为靶标的药物开发提供新的思路和方向。

Brain tumors, especially malignant glioblastoma and melluloblastoma, are often lethal just because of their proliferation and recurrence very quickly. Therefore, it will be difficult problem be solved urgently that exploring of the arising of brain tumor and reasons of brain tumor recur in tumor researching and clinical therapy. Recently, the conception of tumor stem cells and the isolation and identification of brain tumor stem cells provide a new approach to explore the puzzle about the brain tumors. In this review, we will discuss the proposing of tumor stem cell theory and introduce some progress about brain tumor stem cells （including unlimited proliferation, self-renewal, multipotent differentiation, genesis, and so on）. All these researching work will provide one kind of new direction for brain tumor clinical implication such as diagnosis, therapy and development of drug for targeting the tumor stem cells.