Toll-NF-κB信号途径及其介导的功能

The Signal Pathway of Toll-NF-κB and Its Function

Toll样受体(Toll-like receptor,TLR)家族是宿主细胞识别各种微生物致病成份的主要受体,NF-κB位于TLR下游信号通路的枢纽位置,当细胞受到生物应激刺激后激活NF-κB,活化的NF-κB进入细胞核调节炎性细胞因子的表达,启动针对病原微生物的固有免疫和获得性免疫。因此,对Toll-NF-κB信号途径的研究将有助于对免疫反应、炎症病理的理解。

Toll-like receptor （TLR） family is one of the important receptor in cells recognizing of invading pathogens. NF-kB located at key point of TLR down signal pathway and stress activated NF-kB. Activated NF-kB induced the production of inflammatory cytokines and provoked rapid activation of innate immunity and adaptive immunity after entered cell nucleolus. The increasing understanding of ToU-NF-kB signal pathway could be benefit for the understanding of immune response and inflammation pathology.