hDaxx的克隆及其与Pin1之间的相互作用

The Cloning of hDaxx and the Interaction between hDaxx and Pin1

克隆了hDaxx全长的cDNA,并证实hDaxx与肽基脯氨酰异构酶Pin1之间存在相互作用,它们共定位于细胞核内。同时发现它们能够协同激活p53的转录活性,揭示Pin1可能在hDaxx调节细胞凋亡的过程中发挥了重要作用。

In this paper we cloned hDaxx gene and showed the evidence that hDaxx interacted and colocalized with the peptidyl-prolyl isomerase Pinl. By using luciferase reporter assay, we found that hDaxx and Pinl synergically stimulated the transcriptional activity of p53. This founding implicated the Pinl＇s role in the regulation of hDaxx-modulated cell death and provided a potential approach to the understanding of the function of hDaxx.