摘要
雌性生殖道内适宜的液体微环境对一系列生殖事件起至关重要的作用。位于生殖道上皮细胞顶膜或基底膜的一系列离子通道和转运体,通过对水、电解质的跨膜转运,从而调节雌性生殖道内液体的分泌与吸收。本综述着重探讨了上皮细胞钠离子通道和囊性纤维化跨膜电导调节体对雌性生殖道内液体容量和成分的调节以及它们在不同生殖事件,比如精子获能及着床中的重要作用。同时对因离子通道失活或失调引起的雌性生殖道内液体微环境稳态失衡导致的一系列病理改变,如卵巢过度刺激综合征、输卵管积水以及不孕提出了新的见解。
An optimal fluid microenvironment in the female reproductive tract is considered to be crucial for successtul reproducuve events. Fluid absorption and secretion across the reproductive tract epithelia largely depends on electrolyte transport through the apically and basolaterally located ion channels, working together with an array of other transporters. This review will discuss the role of epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane conductance regulator (CFTR) in regulating the fluid volume and composition of the reproductive tract and their importance in various reproductive events such as sperm capacitation and implantation. Disturbance of the fluid microenvironment due to defects or abnormal regulation of these ion channels as causes for a number of pathological conditions, such as ovarian hyperstimulation syndromes, hydrosalpinx and infertility, is also discussed.
出处
《生理学报》
CAS
CSCD
北大核心
2007年第4期495-504,共10页
Acta Physiologica Sinica
基金
This work was supported by the Strategic Program of the Chinese University of Hong Kong and the South China National Research Center for Integrated Biosciences in Collaboration with Zhongshan University.
关键词
囊性纤维化跨膜电导调节体
上皮细胞钠离子通道
上皮细胞
精子获能
着床
感染
cystic fibrosis transmembrane conductance regulator
epithelial sodium channel
epithelial cells
sperm capacitation
implantation
infection