体外授精-胚胎移植后血β-HCG对妊娠结局的预测价值

Value of Serum β-HCG Assay in Early Pregnancy in the Prediction of Pregnancy Outcome after Embryo Transfer

目的:探讨胚胎移植(ET)后血清绒毛膜促性腺激素(β-HCG)水平对妊娠结局的预测价值。方法:选择在我院接受胚胎移植且符合入选条件的669个助孕周期,回顾性分析ET后14天血清β-HCG值。结果:生化妊娠流产组血清β-HCG值与临床妊娠组比较差异有非常显著性(P<0.001),临床妊娠流产组与继续妊娠组血清β-HCG值比较差异有显著性(P<0.01),单胎妊娠与多胎妊娠两组血清β-HCG值比较差异有显著性(P<0.01)。血β-HCG值<100U/L可作为不良妊娠的判断限值,阳性预测价值为84.9%,阴性预测价值为85.9%,血清β-HCG值>1000U/L对多胎妊娠阳性预测价值为68.5%,阴性预测价值为81.1%。结论:ET后14天单次血清β-HCG值可以有效预测妊娠结局。

Objective：To assess the clinical value of serum β- HCG assay in early pregnancy in the prediction of pregnancy outcome after embryo transfer. Methods： 669 embryo transfer （ET） cycles resulting in pregnancy were studied retrospectively. Serum β- HCG concentration were measured on day 14 following ET.Results：The median β- HC, G concentration was 100.8U/L, 192.6U/L, 532.3 U/L, 891,3 U/L in biochemical pregnancies, early spontaneous abortions, ongoing pregnancies, multiple pregnancies respectively, and there was significant difference among them （P〈 0.01 ）, Low β- HCG levels of less than 100U/L predict a more than 84.9% chance of Non - viable pregnancy, whereas levels of more than 1000U/L predict a less than 68.5% chance of multiple pregnancy, Conclusions： A single serum β- HCG level on 14 days after ET provides a useful predictor for pregnancy outcome in IVF.