婴儿性血管瘤24例临床病理分析

Haemangioma of infancy: A clinicopathological study of 24 cases

目的探讨婴儿性血管瘤的临床病理、免疫组化特征以及鉴别诊断。方法采用HE及免疫组化技术对24例婴儿性血管瘤进行观察,并结合文献复习。结果17例呈增殖期图像:细胞丰富,增生的毛细血管排列成小叶状,血管内皮细胞肥胖,管腔不明显,内皮细胞周围为梭形的血管周细胞;7例呈消退期图像:皮下组织中纤维脂肪组织增生,血管减少,残留血管腔扩张,内皮细胞扁平,血管周细胞减少。血管内皮细胞GLUT1阳性,血管周细胞SMA阳性。结论婴儿性血管瘤是儿童期最常见的良性肿瘤,在年龄、性别、发病部位及病程上具有明显特点,组织学特点是肿瘤由血管内皮细胞及血管周细胞组成,内皮细胞特异性表达GLUT1。

Purpose To study the clinicopathological features of haemangioma in infancy. Methods 24 cases of haemangioma in infancy were analyzed with HE stain and immunohistochemical technique, and the relevant literatures reviewed. Results 17 cases were in proliferating phase, which showed hypercellular with lobular proliferation of endothelial and pericytic cells forming small round lumina, and many areas had a solid appearances. 7 cases were in involuting phase, which showed a reduction in the number of vessels and replaced by loose fibroadipose tissue, and the remaining capillary size vessels were dilated with flat endothelial cells. The endothelial ceils were positive for GLUT1, and the pericytic ceils were positive for SMA. Conclusions Haemangioma of infancy is the most common tumor of childhood. It has characteristics in age, sex, site and clinical course. The tumor is composed of GLUT1 positive endothelial cells and SMA positive pericytic cells.