可逆性后部白质脑病2例临床分析

Clinical analysis of 2 cases of reversible posterior leukoencephalopathy syndrome

目的探讨可逆性后部白质性脑病综合征(reversible posterior leukoencephalopathy syndrome,RPLS)的病因、临床表现、影像学特征及治疗。方法分析2例可逆性后部白质脑病综合征患者的临床资料,并复习文献。结果2例患者均有头痛、视物不清、头部MRI检查示T2高信号,其中1例伴有癫发作,经治疗患者的临床表现及影像学均很快好转。结论可逆性后部白质脑病综合征的临床表现无特异性,经对症处理后临床及影像学表现均很快好转。

Objective To investigate the pathogenesis, clinical manifestations, imageology features and treatment of reversible posterior leukoencephalopathy syndrome（RPLS）. Methods To analyse the clinical information of 2 cases of RPLS and review the reference. Results The two patients both had headache, blurred vision and head MRI demonstrating hyperintense lesion on T2 images, one of them had epilepsy. The clinical manifestations and imaging lesions were both improved soon after the effective treatment. Conclusions Analysis of the pathogenesis, clinical manifestations and imageology features of RPLS conduce to clinical diagnosis and helping to the treaded.