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围生期甲状腺功能减退仔鼠行为、学习和记忆研究 被引量：3

On the behaviour,learning and memory in rats with perinatal hypothyroidism
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摘要 旷场试验、避暗试验、放射状八臂迷宫试验等结果显示,围生期甲状腺功能减退仔鼠情绪、空间学习记忆的改变与海马神经元凋亡增加相关。 The results of open-field test, step-through passive avoidance task and radial-arm maze experiment showed that changes of locomotor activity, anxiety-related behaviour and ability of learning and memory were associated with the increased apoptosis of neurons in hippocampus in rats with perinatal hypothyroidism.
作者 黄新文 李筠 季钗 杨荣旺 秦玉峰 赵正言
机构地区 浙江大学医学院附属儿童保健科 浙江大学医学院附属儿童内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第4期358-360,共3页 Chinese Journal of Endocrinology and Metabolism
基金 浙江省重点科技项目基金(021107597) 浙江省医药卫生科学研究基金(2006A073)
关键词 甲状腺功能减退症 围生期 行为 学习 记忆 海马 Hypothyroidism, perinatal Behavior Learning Memory Hippoeampus
分类号 R714.7 [医药卫生—妇产科学] R725.8 [医药卫生—儿科]
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参考文献11

二级参考文献38

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  • 2李晨阳,关海霞,李玉姝,范晨玲,欧阳煜宏,滕颖,丛琦,单忠艳,滕卫平.产后甲状腺炎的前瞻性临床流行病学调查[J].中华内分泌代谢杂志,2005,21(2):99-102. 被引量：62
  • 3李晨阳,单忠艳,关海霞,李玉姝,范晨玲,滕颖,欧阳煜宏,丛琦,滕卫平.碘摄入量对产后甲状腺炎发生、发展的影响[J].中华内分泌代谢杂志,2005,21(2):103-105. 被引量：15
  • 4罗敏,陈淑菁,赵萸,陈家伦.甲状腺激素对大鼠脑特异性基因表达的影响[J].中华内分泌代谢杂志,1994,10(2):94-97. 被引量：4
  • 5Muller Y, Rocchi E, Lazaro JB, et al .Thyroid hormone promotes BCL-2 expression and prevents apoptosis of early differentiating cerebellar granule neurons. Int J Dev Neurosci, 1995, 13: 871-885.
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共引文献56

同被引文献46

  • 1陈祖培,阎玉芹.碘的膳食参考摄入量[J].中华内分泌代谢杂志,2005,21(2):188-192. 被引量：76
  • 2杨茹莱,曹莉佩,周雪莲,黄新文,毛华庆,朱红,赵正言.新生儿期暂时性甲状腺功能减退症的治疗和随访[J].中华内分泌代谢杂志,2005,21(4):361-362. 被引量：6
  • 3Paul W.Ladenson.为我们的儿童而安全补碘(英文)[J].中华内分泌代谢杂志,2006,22(6):507-509. 被引量：5
  • 4Desouza LA, Ladiwala U, Daniel SM, et al. Thyroid hormone regulars hippocarnpal neurogenesis in the adult rat brain. Mol Cell Neurosci, 2005,29:414-426.
  • 5Gould E, Allan MD, McEwen BS. Dendritic spine density of adult hippocampal pyramidal cells is sensitive to thyroid hormone. Brain Res, 1990,525:327-329.
  • 6Zhu DF, Wang ZX, Zhang DR, et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain, 2006,129( Ptl 1 ) :2923-2930.
  • 7Miyakawa T, Yared E, Pak JH, et al. Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components. Hippocampus, 2001,11:763-775.
  • 8Alzoubi KH, Gerges NZ, Alkadhi KA. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CAI: electrophysiological and molecular studies. Exp Neurol, 2005, 195: 330-341.
  • 9Iniguez MA, Rodriguez-Pena A, Ibarrola N, et al. Adult rat brain is sensitive to thyroid hormone. Regulation of RC3/neurogranin mRNA. J Clin Invest, 1992,90:554-558.
  • 10Mons N, Enderlin V, Jaffard R, et al. Selective age-related changes in the PKC-sensitive, calmodulin-blinding protein, neurogranin, in the mouse brain. J Neurochem, 2001,79:859-867.

引证文献3

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中华内分泌代谢杂志
2007年 第4期

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