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宫内发育迟缓幼鼠胰岛素受体底物表达与胰岛素抵抗 被引量：2

Insulin receptor substrate expression and insulin resistance in intrauterine growth retarded rats
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摘要 采用RT-PCR和免疫组化研究胰岛素受体底物(IRS)1和IRS-2在宫内发育迟缓(IUGR)幼鼠组织中的表达与胰岛素抵抗的关系。采用母孕期饥饿法建立IUGR新生大鼠模型。IUGR组出生至3周龄肝组织IRS-2表达水平和骨骼肌组织IRS-1表达水平皆显著低于对照组,并诱导胰岛素抵抗,可能是IUGR易患代谢综合征的分子机制之一。 Insulin receptor substrate （IRS）-1 and IRS-2 expression levels of liver tissues and skeletal muscle in intrauterine ~owth retarded （IUGR） rats were investigated by RT-PCR and immunohistochemistry. An IUGR animal model was established by maternal nutrition restriction during pregnancy. IRS-2 expression level of liver tissue and IRS-1 expression level of skeletal muscle in IUGR rats at 0 and 3 weeks old were significantly lower than those in normal rats at the same age respectively, and insulin resistance was induced in IUGR, and these findings might be the molecular mechanisms susceptible to metabolic syndrome in IUGR rats.
作者 王谦 应艳琴 宁琴 罗小平
机构地区 华中科技大学同济医学院附属同济医院儿科学系
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第4期360-362,共3页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金(30672262) 高等学校博士学科点专项科研基金(20060487063) 卫生部儿科重点学科建设项目
关键词 胎儿生长迟缓 大鼠 SPRAGUE-DAWLEY 胰岛素抵抗 胰岛素受体底物 代谢综合征 Fetal growth retardation Rat, Sprague-Dawley Insulin resistance Insulin receptor substrates Metabolic syndrome
分类号 R725.8 [医药卫生—儿科]
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参考文献9

  • 1Tamemoto H, Kadowaki T, Tube K, et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature, 1994, 372 : 182 -186.
  • 2Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature, 1998,391:900-904.
  • 3王谦,应艳琴,宁琴,罗小平.胰岛素受体底物在宫内发育迟缓新生鼠肌肉组织中的表达[J].实用儿科临床杂志,2006,21(8):460-462. 被引量：3
  • 4Barker DJ, Hales CN, Fall CH, et al. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X ): relation to reduced fetal growth. Diabetologia, 1993,36:62-67.
  • 5Arends NJ, Boonstra VH, Duivenvoorden HJ, et al. Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children bom small for gestational age (SGA). Clin Endocrinol (Oxf), 2005,62:44-50.
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二级参考文献14

  • 1杨速飞,毛萌.建立大鼠宫内生长迟缓模型的方法[J].实用儿科临床杂志,2005,20(2):174-175. 被引量：7
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  • 3Barker DJ,Hales CN,Fall CH,et al.Type 2(non-insulin dependent) diabetes mellitus,hypertension and hyperlipidaemia (syndrome X):Relation to reduced fetal growth[J].Diabetologia,1993,36(1):62-67.
  • 4Arends NJ,Boonstra VH,Duivenvoorden HJ,et al.Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age(SGA)[J].Clin Endocrinol(Oxf),2005,62(1):44-50.
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  • 8Cunningham S,Cameron LT.Consequences of fetal growth restriction during childhood and adult life[J].Curr Obstetr Gynaecol,2003,13:212-217.
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  • 10Gluckman PD,Hanson MA.The developmental origins of the metabolic syndrome[J].Trends Endocrinol Metab,2004,15(4):183-187.

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中华内分泌代谢杂志
2007年 第4期

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