从人类能量代谢进化视角理解肥胖发生机制

Understanding of obesity pathogenesis from human energy metabolism evolution perspective

本文从人类进化视角,阐述肥胖易感基因过氧化物酶体增殖物激活受体家族(PPARs)和PPARγ共激活因子1(PGC-1)家族基因多态性的进化背景与肥胖表征的关系,并阐述人类进化过程中影响能量储备能力形成及发展的重大事件,旨在较深入理解人类肥胖易感性的生物进化原因,并为肥胖防治策略提供新思路。

This article elucidates the relationship between the human susceptibility to obesity and gene polymorphisms such as peroxisome proliferators-activated receptors （PPARs） and PPARγ coactivator-1, along with milestones in the formation and development of capacity for fat deposition during evolutionary history of human. An biological evolutionary analysis, identifying factors favoring the energy stores, may be helpful to the development of preventive public health strategies.