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Synthesis of 12-alkoxycarbonylmethylene-1,15-pentadecanolides

Synthesis of 12-alkoxycarbonylmethylene-1,15-pentadecanolides
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摘要 Six novel 12-alkoxycarbonylmethylene-1,15-pentadecanolides (3) were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Homer reaction. Their structures were confirmed bv 1H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity. Six novel 12-alkoxycarbonylmethylene-1,15-pentadecanolides (3) were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Homer reaction. Their structures were confirmed bv 1H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第8期915-916,共2页 中国化学快报(英文版)
关键词 12-Alkoxycarbonylmethylene-1 15-pentadecanolide MACROLIDE Acrylic ester Wittig-Horner reaction Fungicidal actictity 12-Alkoxycarbonylmethylene-1, 15-pentadecanolide Macrolide Acrylic ester Wittig-Horner reaction Fungicidal actictity
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