海洋真菌中Actinopyrone A and C的分离与结构解析(英文)

Structure Elucidation of Actinopyrone A and C Isolated from Marine Fungus Penicillium sp.

应用各种层析手段(Sephadex LH-20,硅胶Silica和RP-8柱层析),从海洋真菌发酵液中分离纯化了2个actinopyrone类化合物,结合多种波谱方法(HRESI-MS,1D NMR,2D NMR),确定了它们的结构为:actinopyrone A和C.利用NOESY试验确定了它们的相对构型,并根据HMBC数据纠正了这2个化合物C-21(H-21)位和C-22(H-22)位的化学位移.

Two antibiotic compounds, actinopyrone A （1） and C （2） were separated from lyophilized culture broth of marine fungus Penicillium sp. and their structures were elucidated with 1D and 2D NMR and HR-ESI-MS. The relative stereocbemistry of compounds 1 and 2 was determined by analyzing the NMR NOESY data. Based on the NMR HMBC data, the erroneous chemical shifts of C-21 （H-21） and C-22 （H-22） reported in the literature were corrected.