药物核磁共振定量分析参数的研究

Studies of NMR Acquisition Parameters for Quantitative Analysis of Drugs

药物核磁共振定量分析已见诸多篇报道.英、美、欧药典中都先后引入了核磁共振分析方法.本文对药物核磁共振定量分析的参数作了较为详尽的研究,提出了选择定量特征峰的新标准.经维生素C实际样品测定其精密度优于1%,结果满意.

The principles underlying selection of NMR acquisition parameters （i. e. , relaxation delay time, pulse width and number of transient etc. ） for quantitative analysis of drugs were discussed in detail. Some requirements on selecting appropriate peaks for quantitative analysis were proposed. We showed that the methyl peak is not suitable for quantitative analysis because it often has long relaxation time. With the principles discussed, the content of vitamin C determined by quantitative NMR analysis was found to have relative standard deviation less than 1%.