腺样胶质母细胞瘤临床病理观察

Adenoid glioblastoma:a clinicopathological observation and review of literature

目的提高对胶质母细胞瘤的某些特殊形态类型的认识。方法采用HE染色、免疫组化对1例术后病理证实为腺样胶质母细胞瘤的病例进行详细的观察。结果该例组织形态为多中心生长,某些区域出现片、巢状生长,并见腺样及乳头状结构,类似转移性腺癌。结论肿瘤上皮分化区表达胶质纤维酸性蛋白(GFAP)而上皮类标记物阴性将有助于排除转移癌而明确肿瘤为胶质细胞来源。

Objective Tor improve the recognization of some special morphological types of glioblastoma. of glioblastoma contained foci epithelial differentiation （adenoid glioblastoma） was analyzed with HE and stains and review of the literature. Results In this case, the lesions had multicentral growth, some areas appeared sheet and nest patterns, also with glandular and papillary epithelial structures, similar to metastatic adenocarcinoma. Conclusion the expression of GFAP in those areas may help exclude the metastatic carcinomas and confirm its astrocytic nature.