福建地区571例IgA肾病流行病学特点

The clinicopathological and epidemic characteristics of 517 cases with IgA nephropathy in Fujian area

目的探讨福建地区IgA肾病的流行病学及临床病理特点。方法回顾性分析本地区571例IgA肾病的流行病学及临床病理特点。结果发病年龄≤20以下占17．0％，21～30岁占36．1％），31～40岁占24．5％，41～50岁占21．7％，50岁以上仅为1．7％。蛋白尿发生率高达93．0％；伴高血压病者15．9％0，肾功能不全者14．3％。临床表现以无症状性尿检异常型最常见（占39．4％0），病理类型以弥漫性系膜增生性肾小球肾炎（MsPGN）伴局灶节段肾小球硬化（FSGS）最为常见（占31．9％），MsPGN占27．5％，局灶节段系膜增生性肾炎（FsPGN）占22．6％，其他类型占18．0％），肾小管间质损害以中度损害为主（71．6％）。免疫病理类型以IgAMG型占53．1％，IgAG型占21．0％，其他类型占25．9％。IgA肾病出现慢性肾功能不全时，以FSGS病理类型最常见。结论福建地区IgA肾病流行病学及临床病理存在一定的地区特点：老年人比例少，蛋白尿比例高，最常见病理类型是MsPGN伴FSGS，免疫病理以IgAMG型最常见，肾小管间质病变较重。

Objective To explore the epidemic and clinicopathological characteristics of IgA nephropathy in Fujian area, Method The clinical and pathological characteristics of 517 cases with IgA nephropathy in Fujian area were analyzed retrospectively. Results Among all 517 patients with IgA nephropathy（IgAN）in Fujian area, there were 60. 6% of the patients between 20- 40 years old, but only 1.7% of the patients aged over 50 years old. There were 93.0 % of the patients with proteinuria, 15. 90% the patients with hypertension, 14. 29% the patients with renal dysfunction. Asymptornatic abnormal urinalysis was the most common clinical manifestation （39.4%）. Pathologically, mesangial proliferative glomerulonephritis accompanied with focal segmental glomerulosclerosis（MsPGN accompanied with FSGS） was the most frequent type （31.9 % ）. The moderate tubulointerstitial damage was the most cornmom（71.6% ）. The most typy of immmunopathologic typies was IgAMG. FSGS was the most frequent pathological type in the patients with chronic renal insufficiency. Conclusions There were some epidemic and clinicopathological characteristics of IgAN in Fujian area, such as.. the proportion of older persons was small, the proportion of proteinuria was high, MsPGN with FSGS was the most frequent Pathological type.