SICAM-1在乙型肝炎患者血清中的表达

Expression of SICAM-1 in serum of hepatitis B patients

[目的]观察SICAM-1在乙型肝炎患者血清中的表达,探讨SICAM-1与病情的关系。[方法]用酶联免疫分析法(ELISA)检测60例乙肝患者和30例健康对照者血清中的SICAM-1水平,同时测定谷丙转氨酶和谷草转氨酶的浓度。[结果]转氨酶升高的乙肝患者血清中SICAM-1的水平(201.26±98.69)ng/mL明显高于正常对照组(35.32±10.67)ng/mL(P<0.01)并且高于转氨酶正常乙型肝炎组(36.32±10.67)ng/mL(P<0.01),转氨酶正常乙型肝炎组(36.32±10.67)ng/mL与正常对照组SICAM-1的水平(35.32±10.67)ng/mL差异无显著性意义(P>0.05)。[结论]转氨酶升高的乙肝患者血清中SICAM-1的水平显著升高,表明SICAM-1参与肝炎发病过程,并与发病程度相关,可作为衡量乙型肝炎患者肝损害程度的指标之一。

[Objective] To investigate expression of SICAM -1 in the serum of hepatitis B patients and its relation with diseases. [ Methods ] SICAM - 1 level of 60 hepatitis B patients and 30 healthy control were detected by ELASA , in step detected ALT and AST level. [ Results] SICAM -1 in hepatitis B patients whose transaminase increased （201.26 98.69）ng/mL were evidently higher than that in control （35.32 ± 10.67） ng/mL and in hepatitis B patients whose transaminase were normal （ 36.32 ± 10.67 ） ng/mL （ P 〈 0. 01 ）, there was no difference between control groups （ 35.32 ± 10.67 ） ng/mL and normal groups 36.32 10.67 ng/mL （ P 〉 0. 05 ）. [ Conclusion] SICAM- 1＇s high level in hepatitis B patients with high transaminase suggests that SICAM takes part in the process of hepatitis episode and it is correlated with degree of the illness . SICAM can act as one of markers evaluating degree of liver injury in hepatitis B patients.