兔慢性高眼压模型的眼部表现

Change of rabbits' eyeballs with chronic intraocular hypertension

目的:观察慢性高眼压状态对兔眼及其视盘的影响。方法:新西兰白兔,10眼前房内抽出0.2mL房水后注射0.2mL复方卡波姆溶液,使眼压慢性升高,10眼为对照组。每天测眼压1次,4wk后,眼底照相,并取出视盘周围视网膜及球后视神经制片,镜下观察。结果:对照组眼前节、视盘、筛板等正常;高眼压组眼部有明显的变化,视盘加深、筛板处形态显著凹陷。结论:高眼压模型眼部改变明显,尤其是视盘筛板更接近临床慢性青光眼的改变。

AIM： To investigate the changes of rabbits＇ eyes with chronic increase of intraocular pressure （IOP）. METHODS： IOP was increased chronically in 5 rabbits by an injection of 0.2mL compound carbomer solution into anterior chamber, and the other 5 rabbits were served as control. The intraocular pressure （IOP） was measured every day. After 4 weeks, eyeground photographs were taken. All optic nerves and retinas of rabbits were examined by a conventional microscope. RESULTS： The anterior segment of eye, optic disk and cribrum appearance of the eyeball looked normal in control eyes in all specimens. While in experimental eyes, the optic disk was deepened, and cribrum was deformed. CONCLUSION： Chronic intraocular hypertension significantly affects the eyeball. This change might be responsible for the irreversible damage of visual activity induced by chronic intraocular hypertension, similar to clinic manifestation of chronic glaucoma.