下肢深静脉血栓形成的溶栓治疗

Thrombolytic therapy of lower extremity deep venous thrombosis

目的:探讨下肢深静脉血栓形成的治疗方法。方法:50例经彩超、D-二聚体证实为下肢深静脉血栓形成患者,其中常规组24例,采用普通肝素、低分子量肝素、华法林治疗,溶栓组26例在上述治疗的基础上,加用尿激酶治疗。结果:常规组中,20例基本治愈,2例有效,2例无效;溶栓组中,基本治愈者25例,有效者1例,无无效病例;两组差异无统计学意义(P>0.05)。达到临床治愈时间:常规组平均15 d,溶栓组平均11 d,两组差异有统计学意义(P<0.05)。结论:下肢深静脉血栓形成患者早期应用肝素、华法林结合尿激酶等治疗,可显著提高疗效。

Objective To approach the method of treating lower extremity deep venous thrombosis. Methods Lower extremity deep venous thrombosis was confirmed with ultrasonic cardiogram and D-dimer in 50 patients. The routine group（24 cases） was treated with UFH,LMWH and warfarin. The thrombolytic group（26 cases） was treated with UFH,LMWH,warfarin and UK. Results Twenty cases were cured, 2 cases were improved, and 2 cases had noefficacy in routine group. Twenty-five cases were cured, and 1 case was improved in thrombolytic group. There was no statistic difference between two groups（P〉0. 05）. The time to achieve clinical curing was 15 days in routine group and 11 days in thrombolytic group （P〈0. 05）. Conclusion Therapeutic effect is improved greatly in lower extremity deep venous thrombosis patients, if heparin, warfarin and UK are used early.