摘要
为探讨共刺激信号Ｂ７－２对基因免疫应答的影响，将小鼠Ｂ７－２基因的真核表达质粒ｐｃＤＮＡ３ｍｂ７－２与戊型肝炎病毒核酸疫苗ｐＳＶＬ－ＨＥＶＯＲＦ３混合注射到Ｂａｌｂ／ｃ小鼠骨骼肌内。实验结果显示，肌肉内混合注射Ｂ７－２基因真核表达质粒未能提高核酸疫苗接种引发的体液免疫应答，并对可能的原因进行了讨论。
To study the influence of costimulatory signal B7 2 on the immune response stimulated by genetic immunization,plasmid DNA expressing murrain B7 2 was co injected intramuscularly with HEV DNA vaccine into Balb/c mice.The circular anti HEV IgG were detected by ELISA method.The anti HEV IgG titer of the group co injected with B7 2 expressing plasmid DNA was not higher than that of the group inoculated with HEV DNA vaccine alone.
基金
自然科学基金
