期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

电喷雾质谱法研究聚酰胺、酰亚胺衍生物与HIV-1基因DNA的相互作用 被引量：4

Investigation of Interaction of HIV-1 DNA and Polyamides,Imide Derivatives by Electrospray Ionization Mass Spectrometry
下载PDF
导出
摘要 利用电喷雾质谱(ESI-MS)研究了6种识别分子与HIV-1基因调控区DNA的非共价键相互作用.在研究中比较了不同识别分子与靶序列DNA结合的强弱,发现双萘酰亚胺衍生物4对此序列DNA具有高亲合性的结合,并分析了识别分子与DNA复合物的碎裂机理以及结合模式. 　Electrospray ionization mass spectrometry was utilized to investigate the non-covalent interaction of HIV-1 gene and six DNA-recognizing molecules.It revealed that imide derivative 4,a potent binder of HIV-1 DNA,had the higher binding affinity with the duplex DNA among six DNA-recognizing molecules.
作者 李卉卉 韩德伟 袁谷
机构地区 北京大学化学学院化学生物学系北京分子科学国家实验室生物有机与分子工程教育部重点实验室
出处 《化学学报》 SCIE CAS CSCD 北大核心 2007年第16期1543-1547,共5页 Acta Chimica Sinica
基金 国家自然科学基金(No.20472009)资助项目.
关键词 HIV-1基因 ESI-质谱法 DNA识别分子 寡聚酰胺 酰亚胺衍生物 HIV-1 gene ESI-MS DNA-recognizing molecule polyamide imide derivative
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献10

  • 1Gottesfeld,J.M.; Neely,L.; Trauger,J.W.; Baird,E.E.;Dervan,P.B.Nature 1997,387,202.
  • 2Wemmer,D.E.; Dervan,P.B.Curr.Opin.Struct.Biol.1997,7,355.
  • 3Dervan,P.B.; Burli,R.W.Curr.Opin.Chem.Biol.1999,3,688.
  • 4White,S.; Szewczyk,J.W.; Turner,J.M.; Baird,E.E.;Dervan,P.B.Nature 1998,391,468.
  • 5Dervan,P.B.Bioorg.Med.Chem.2001,9,2215.
  • 6Brana,M.F.; Castellano,J.M.; Moran,M.; Perez De Vaga,M.J.; Romerdahl,A.; Qian,X.-D.; Bousquet,P.; Emiling,F.; Schlick,E.; Keilhauer,G.Anti-Cancer Drug Des.1993,8,257.
  • 7Baily,C.; Brana,M.F.; Waring,M.J.Eur.J.Biochem.1996,240,195.
  • 8周江,袁谷.DNA识别分子研究的进展[J].有机化学,2003,23(6):526-541. 被引量：7
  • 9李钦玲,周江,汤菲力,袁谷.聚酰胺类DNA识别分子质谱的碎裂机理[J].化学学报,2005,63(9):834-840. 被引量：3
  • 10Li,H.H.; Yuan,G.J.Am.Soc.Mass Spectrom.2006,17,1742.

二级参考文献11

  • 1Trauger, J. W., Baird, E. E.; Dervan, P. B. Nature 1996,382,559.
  • 2Gottesfeld, J. M.; Neely, L.; Trauger, J. W.; Baird, E. E.;Dervan, P. B. Nature 1997, 387, 202.
  • 3Geierstanger, B. H.; Mrksich, M.; Dervan, P. B.; Wemmer,D. E. Science 1994, 266, 646.
  • 4Kielkopf, C. L.; White, S.; Szewczyk, J. W. Science 1998,282, 111.
  • 5Tang, F.-L.; Wang, J.; Liu, D.; Yuan, G.; Liu, Y.; Zhu, C.-J.;Zhao, Y.-F. Rapid Commun. Mass Spectrom. 2002, 16,1035.
  • 6Yuan, G.; Tang, F.-L.; Zhu, C.-J.; Liu, Y.; Zhao, Y.-F.Rapid Commun. Mass Spectrom. 2003, 17, 2015.
  • 7Xiao, J.-H.; Yuan, G.; Huang, W.-Q.; Chart, A. S. C.; Lee,K. L. D. J. Org. Chem. 2000, 65, 5506.
  • 8Xiao, J.-H.; Yuan, G.; Huang, W.-Q.; Du, W.-H.; Wang,B.-H.; Li, Z.-F. Chin. J. Chem. 2001, 19, 116.
  • 9Tang, F.-L.; Wang, J.; Liu, D.; Li, J.-J., Yuan, G. J. Chin.Chem. Soc. 2002, 49, 1.
  • 10YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China,Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China,Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China,National Hybrid Rice R & D Center, Changsha 410125, China,Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China,College of Life Sciences, Peking University, Beijing 100871, China,Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China,Digital China Ltd., Beijing 100080, China,Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China,Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden.A draft sequence of the rice (Oryza sativa ssp. indica) genome[J].Chinese Science Bulletin,2001,46(23):1937-1942. 被引量：8

共引文献6

同被引文献20

引证文献4

二级引证文献15

化学学报
2007年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部