摘要
用四氢噻唑-2-硫酮(TTT)分解赖氨酸-铜配合物,合成侧链氨基被选择性保护的赖氨酸衍生物Nα-Boc-Nε-Fmoc-L-Lys-OH.研究结果表明四氢噻唑-2-硫酮分解氨基酸铜配合物比传统试剂(H2S,EDTA,HCl)速度快,反应彻底,且副产物易除去.
A lysine derivative with selectively protected side chain N^α-Boc-N^ε-Fmoc-L-Lys-OH was synthesized through decomposition of lysine cupric complex with tetrahydrothiazole-2-thione（TTT）.The results indicate that the decomposition is faster and more complete,the by-product was easier to be removed than that with traditional reagents（H2S,EDTA,HCl）.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2007年第16期1654-1656,共3页
Acta Chimica Sinica
