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溶液pH和阳离子对端粒G-四链体DNA形成和结构的影响 被引量：8

Effect of pH and Cations on the Formation and Structure of Human Telomeric G-Quadruplex DNA
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摘要 采用电喷雾质谱和圆二色谱研究了溶液pH和阳离子对人类端粒G-四链体DNA的影响.ESI-MS和CD谱图表明,pH可以引起G-四链体DNA的构象转变和离解,而K+,NH+4阳离子对G-四链体DNA的形成有着重要的促进作用. 　Electrospray ionization mass spectrometry and circular dichroism were used to investigate the factors which affect the motif of the human telomeric quadruplex,such as pH and cations.ESI-MS and CD spectra indicated that pH could induce both the conformational transition and the dissociation of the quadruplex.Moreover,K^＋ and NH4^＋ cations play an important role in the formation of the quadruplex.
作者 周江 袁谷
机构地区 北京大学化学与分子工程学院化学生物学系北京分子科学国家实验室生物有机与分子工程教育部重点实验室
出处 《化学学报》 SCIE CAS CSCD 北大核心 2007年第16期1728-1732,共5页 Acta Chimica Sinica
基金 国家自然科学基金(Nos.20272005 20472009)资助项目.
关键词 端粒 G-四链体DNA ESI-质谱法 圆二色谱 telomere G-quadruplex DNA ESI mass spectrometry circular dichroism
分类号 Q523 [生物学—生物化学]
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化学学报
2007年 第16期

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