紫红獐芽菜对刀豆蛋白A所致肝损伤的保护作用

The protective effect of Swertia Punicea in concanavalin A-induced liver injury in mice

]目的:观察紫红獐芽菜对ConA性肝损伤小鼠的影响。方法:测定该药对ConA性肝损伤小鼠的血清ALT、AST活性和NO含量的影响,并观察肝脏和脾脏指数的变化情况。结果:紫红獐芽菜明显抑制ALT、AST含量的升高,降低NO的含量及降低肝脏指数和脾脏指数,并呈剂量依赖趋势。紫红獐芽菜高、中剂量组与联苯双酯作用相似,而低剂量组不及联苯双酯。结论:紫红獐芽菜对ConA所致小鼠肝损伤具有较好的保护作用,其保肝机制与抑制NO的产生有一定关系。

Objective：To investigate the protective effects of Swertia Punicea on liver injury in mice induced by concanavalin A （Con A）. Methods：To measure activities of serum ALT,AST and content of nitric oxide（ NO）,and to observe changes of the liver index as well as the spleen index. Results：Swertia Punicea obviously inhibited the rising levels of serum ALT,AST and NO, meanwhile decreased the liver index and the spleen index. These results apparently decreased in both high and middle dosage groups of Swertia Punicea.Conclusion：Swertia Punicea have protection liver and decreasing enzyme action on liver injury in mice induced by ConA.It may through the way of suppressing the release of NO.