摘要
在感染人免疫缺陷病毒1型的人T细胞CD4的CEMs细胞中,应用核酸杂交法检测病毒RNA水平,观察前列腺素A1对人免疫缺陷病毒1型复制作用的影响。结果表明,在低感染多重性下,用前列腺素A1处理组,病毒RNA水平在病毒感染72~96小时明显低于对照组,感染24小时后给予前列腺素A1,仍可抑制病毒RNA。连续用前列腺素处理,其抑制作用达9天。
We observed the effect of prostaglandins A1 (PGA1) on the replication of HIV-1 by Northern-blot method in the CEM-ss cells which had been infected with HIV-1. The results showed that the RNA levels of HIV-1 in infected cells treated with PGA1 was lower than that of controls in low MOI 72-96 hours postinfection. The RNA of HIV-1 was dramatically reduced in infected CEM-ss cells when PGA1 was given 24 hours postinfection. The inhibition effect of PGA1 lasted for 9 days when PGA1 was given constantly.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1997年第1期53-55,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
前列腺素A1类
免疫缺陷病毒
复制
Prostaglandins A1 Human immunodeficiency virus type 1 Replication