新抗菌靶点肽去甲酰基酶抑制剂的研究进展

The Evolution of the Inhibitors of Peptide Deformylase as a New Antibacterial Target

综述新抗菌靶点肽去甲酰基酶在细菌蛋白合成中的作用、三维结构及其抑制剂的设计、发现与开发和耐药菌的产生。随着细菌耐药性的广泛发生以及多药耐药菌的出现,临床上急需对耐药菌有效的新型抗菌药,而寻找新型抗菌靶点为抗耐药菌药物的研究提供了新思路。

The role in bacterioprotein biosynthesis and 3D structure of peptide deformylase as a new antibacterial target and the design, discovery and development of its inhibitors as well as the emergence of drug resistance were reviewed. There is an urgent clinical need to develop novel antibacterials against drug resistant bacterial pathogens now, with the appearance of the wide-spread antibacterial resistance and emergence of multi-drug resistant bacterial pathogens.