单环β-内酰胺类胆固醇吸收抑制剂的研究与开发

Research and Development of β-lactam Cholesterol Absorption Inhibitors

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摘要综述单环β-内酰胺类胆固醇吸收抑制剂的发现、β-内酰胺母核上不同取代的构效关系研究、依泽替米贝的设计及其他单环β-内酰胺衍生物的开发。单环β-内酰胺类化合物是一类通过有效阻断小肠内胆固醇吸收而发挥作用的降血脂药物。 The discovery of monocyclic β-lactam cholesterol absorption inhibitors, structure-activity relationship of substitution on the heterocyclic nucleus, design of ezetimibe and development of other monocyclic β-lactam analogs were reviewed. Monocyclic β-lactam compounds am a novel calss of antihyperlipidemic drugs via potent inhibition of cholesterol absorption in small intestine.

作者纪剑峰黄文龙张惠斌

机构地区中国药科大学新药研究中心

出处《药学进展》 CAS 2007年第8期342-349,共8页 Progress in Pharmaceutical Sciences

关键词单环β-内酰胺胆固醇吸收抑制剂依泽替米贝构效关系 Monocyclic β-1actam Cholesterol absorption inhibitor Ezetimibe Structure-activity relationship

分类号 R972 [医药卫生—药品]

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单环β-内酰胺类胆固醇吸收抑制剂的研究与开发

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