摘要
目的:探讨细胞因子白介素-18(IL-18)、干扰素(IFN-γ)在儿童病毒性心肌炎(VM)发病中的意义。方法:用双抗体夹心ELISA法检测72例VM患儿(VM组)及25例健康儿童(对照组)血清IL-18、IFN-γ的含量。结果:(1)VM组血IL-18、IFN-γ含量高于对照组(P<0.05)。VM组肌酸磷酸激酶MB亚型(CKMB)升高者血IL-18的含量高于CKMB正常者(P<0.05),但血IFN-γ含量差异无统计学意义(P>0.05)。(2)VM组血清IL-18含量与CKMB含量呈直线正相关(r=0.46,P<0.05)。(3)VM患儿治疗后血IL-18、IFN-γ的水平较治疗前明显下降(P<0.05)。结论:血清中细胞因子IL-18、IFN-γ参与了儿童病毒性心肌炎发病的免疫过程;血清IL-18的水平可作为诊断的一项辅助指标;而治疗后血IL-18、IFN-γ水平的变化,可用于评价预后和疗效的参考标准。
Objective：To investigate the clinical significance of cytokine,interleukine-18（IL-18）and interferon-γ（IFN-γ）in children with viral myocarditis（VM）.Methods：The levels of serum cytokine IL-18 and IFN-γ were detected by enzyme-linked immunosorbent assay（ELISA）in 72 children with acute VM（VM group）and 25 healthy children（control group）.Results：（1）The levels of serum cytokine IL-18 and IFN-γ were significantly higher in VM group compared to those of control group（P 〈 0.05）.The level of IL-18 was significantly higher in CKMB abnormal group compared to that of CKMB normal group（P 〈 0.05）.There was no significant difference in level of IFN-γ between two groups（P 〉 0.05）.（2）The level of serum IL-18 had positive correlation with the level of serum CKMB（r = 0.46,P 〈 0.05）.（3）The levels of serum cytokine IL-18 and IFN-γ were significantly decreased after treatment in VM group（P 〈 0.05）.Conclusion：Cytokine IL-18 and IFN-γ played roles in the VM pathogenesis.The level of serum IL-18 level could be one of index for diagnosing of VM.The changes of serum IL-18 and IFN-γ in the VM patients after therapy can be used to evaluate prognosis and the effect of therapy.
出处
《天津医药》
CAS
北大核心
2007年第8期569-571,共3页
Tianjin Medical Journal
