原发性肝癌的综合治疗——附322例报道

Comprehensive Therapy for Primary Liver Cancer (A Report of 322 Cases)

目的:探讨原发性肝癌综合治疗的方法,进一步提高肝癌的整体治疗效果。方法:回顾性分析322例肝癌患者的手术切除治疗、非手术治疗及未行治疗的临床资料,并进行生存率、术后复发率比较。结果:①手术切除组1、3、5年术后复发率为32.3%、71.5%、81.5%,围手术期手术死亡率为0.93%。②切除组患者存活1年和3年者为78.5%和56.1%,非切除组42.0%和6.1%,前者显著高于后者(P<0.01)。③未接受任何治疗者均于诊断后1年内死亡,其1年和3年存活率均为0%,均显著低于手术切除组和非手术切除组。结论:综合治疗能有效提高手术安全性和切除率,降低术后肿瘤复发,提高肝癌的整体治疗效果。

Objective Investigate the methods of comprehensive therapy for primary liver cancer （PLC）, to improve the therapeutic efficacy of PLC. Methods A retrospective analysis of 322 patients with PLC who accepted hepatectomy、non-hepatectomy or non-treatment, and compare the survival rates and recurrent rates. Results ①Of the resectable group, the overall 1、3、5-year recurrent rates were 32.3%、71.5%、81.5%, respectively; the overall mortality rate after operation was 0.93%. ②Of the resectable group, the overall 1、3 - year survival rates were 78.5% and 56.1%, that were 42.0% and 6.1% in nonresectable group, the frontal one was evidently higher than the latter （P 〈 0.01）. ③The patients without any treaments died within 1 year after diagnosis, which 1、3-year survival rates were all 0%. That was evidently lower than resectable group and nonresectable group. Conclusion Comprehensive therapy can effectively improve the security of operation and the resectable rate, reduce the postoperative recurrence of tumor, and improve the whole therapeutic effect of PLC.