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心肌缺血后处理研究新进展

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摘要 急性心肌梗死目前是临床致残和致死的主要原因，其根本解决方法就是恢复心肌的正常血液供应。随着经皮冠状动脉腔内成形术、冠状动脉溶栓术和冠状动脉旁路移植术的广泛应用，心脏缺血，再灌注损伤越来越受到关注。1986年Murry等首先在犬心模型中发现缺血预处理现象，此后的大量研究证实可以应用预处理对抗缺血，再灌注损伤。2003年Zhao等首先在犬心模型中发现缺血后处理现象，并认为可以减轻再灌注损伤。现就有关研究作一综述。
作者 晏浩 徐建军
机构地区 南昌大学第二附属医院心胸外科
出处 《中华胸心血管外科杂志》 CSCD 北大核心 2007年第4期281-283,共3页 Chinese Journal of Thoracic and Cardiovascular Surgery
关键词 急性心肌梗死 缺血后处理 经皮冠状动脉腔内成形术 冠状动脉旁路移植术 再灌注损伤 冠状动脉溶栓术 缺血预处理 血液供应
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1Murry CE, Jennings RB, Reimer KA, et al. Preconditioning with ischemia a delay of lethal cell injury in ischemic myocardium. Circulation, 1986,74, 5: 1124- 1136.
  • 2Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol, 2003,285 : 579 - 588.
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二级参考文献43

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共引文献47

中华胸心血管外科杂志
2007年 第4期

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