犬颈外动脉内支架置入对被覆盖分支血管的影响

Experimental study on the effects of intravascular stents placement that covering canine's branch arteries

目的通过犬颈外动脉血管内支架置入,观察支架置入后不同时间对置入段分支血管通畅性的影响,探讨血管内支架治疗脑血管疾病安全性。方法将11个血管内支架置入11只杂种犬颈外动脉,分别于支架置入后即刻、1个月、3个月行脑血管造影复查,观察分支血管是否通畅、是否狭窄或闭塞及分支血管血流动力学是否受影响。结果10枚支架放置成功。即刻血管造影,主干血管通畅率100%,10枚支架置入10根主干血管,共覆盖了12根分支血管。支架置入术后即刻、1个月、3个月造影见开口于支架置入段血管的分支血管均保持通畅,术后1个月时造影可见新生内膜覆盖支架,内膜光滑,厚度均匀。3个月造影显示2例分支血管开口轻度狭窄,但对分支血管血流动力学没有明显影响。结论犬颈外动脉血管内支架置入即刻对分支血管无影响,短期造影随访可见2例分支血管开口略有狭窄,但对血液动力学没有明显影响。

Objective To evaluate the effects on the patency of the stented segments branch artery in different time after intravascular stent placement and investigate the safety on the treatment of intracranial disease with intravascular stent. Methods Eleven mesh stents were deployed in the carotid external arteries （ECA） that across the branches arteries in eleven mongrel canines. In each ECA,one stent was deployed. Digital substraction angiograpby was performed to evaluated the patency of the branch artery at immediate, 1 month and 3 month after stents were placed. Result The stenting procedures were technically successful in ten canines. Twelve trunk arteries were covered, the patency rate of trunk arteries were 100% at immediate angiography, all side branches from stented segment were patent in the immediate, 1 month,3 month follow- up. DSA showed that the neointima bad grown onto the strut at 1 month follow-up, angiograpbic follow-up reavealed mild stenosis after 3 months in two canines. Conclusion The patency rate of branch arteries that origined from stented segments were 100% at immediate angiograpby after intravascular stents were placed. Mild stenosis have been found during short-term follow-up. We have not found obvious disadvantages.