人非小细胞肺癌与外周血淋巴细胞表达LRP的相关性研究

Correlation between expression of lung resistance-related protein in non-small cell lung cancer and that in peripheral blood lymphocytes

目的探讨肺耐药相关蛋白(lung resistance-related protein,LRP)在人非小细胞肺癌(non-small cell lung cancer,NSCLC)癌组织、癌旁组织和外周血淋巴细胞(peripheral blood lymphocytes,PBL)中的表达及其相关性。方法采用S-P免疫组织化学方法检测49例人NSCLC癌组织、癌旁组织和PBL中LRP的表达及10例正常人PBL中LRP的表达。结果NSCLC癌组织、癌旁组织和PBL的LRP表达阳性率分别为78.2%、46.4%和66.8%,其中癌组织的LRP表达阳性率明显高于癌旁组织(P<0.05),且与PBL的LRP表达呈正相关。在各病理类型的NSCLC中,腺癌表达阳性率最高(90.9%),鳞癌次之(55.6%),差异显著(P<0.01)。10例正常人PBL的LRP表达阳性率(20%)显著低于NSCLC患者(P<0.05)。结论检测NSCLC患者PBL的LRP表达可间接反映癌组织的LRP表达状况。

Objective To explore the correlation between the expression of lung resistance-related protein （LRP） in non-small cell lung cancer （NSCLC） and that in peripheral blood lymphocytes （PBL）. Methods The S-P immunohistochemistry was used to detect the expression of LRP in specimens and PBL of 49 patients with NSCLC. Para-carcinoma tissues and PBL of 10 normal people were used as controls. Results The positive expression rate of LRP was 78.2% , 46.4% and 66.8% in carcinoma tissues, para-carcinoma tissues and PBL, respectively. The expression rate of LRP in carcinoma tissues was higher than that in para-carcinoma tissues （ P 〈 0.05 ） , and positively correlated with that in PBL of the patients. The expression rate of LRP in adenocarcinomas was higher than that in squamous cell carcinomas （ P 〈 0.01 ）. The expression rate of LRP in the normal people was lower than in NSCLC patients（P 〈 0.05 ）. Conclusion The expression of LRP in PBL of NSCLC patients may indirectly represent the expression of LRP in carcinoma tissues.