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氯胺酮和氯诺昔康对慢性关节炎疼痛治疗的实验研究 被引量:2

The Experimental Study of Ketamine and Lornoxicam on Chronic Arthritis Pain in Rat
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摘要 目的研究氯胺酮、氯诺昔康及两药联合关节内注射对慢性关节炎疼痛的疗效.方法大鼠右踝关节注射完全弗氏佐剂建立单发性关节炎模型,4周后,关节内注射氯胺酮、氯诺昔康及两药联用,每周3次,共用药2周.踝关节X线照片、关节病理切片、关节直径值、屈关节疼痛试验评分和血浆谷氨酸含量为指标.结果踝关节X线照片和病理切片结果提示慢性炎症存在.用药前实验组右踝关节直径值、屈关节疼痛试验评分、血浆谷氨酸含量显著高于对照组(P<0.05);用药2周3个用药组疼痛评分、血浆谷氨酸含量显著低于非用药组,其中氯诺昔康组和联合组右踝关节直径显著低于非用药组(P<0.05),且2组关节病理切片均见到有新生关节软骨的形成.结论关节内注射氯胺酮和氯诺昔康均可缓解慢性关节炎疼痛,氯诺昔康较氯胺酮抗炎作用明显,还可促进受损关节的修复,联合注射氯胺酮和氯诺昔康,可大大减少两药的用量. Objective To research the effects of injection of ketamine and lornoxicam in joint cavity for the treatment of rat chronic arthritis pain. Methods Injection of complete Freund' s adjuvant into the right tibio - tarsal joint produced a reliable monoarthritic model. After 4 weeks, rats were injected in right ankle joint cavity with ketamine and lornoxicam respectively and combinatorially, 3 times per week for a total of 2 weeks. X - ray, the pathological section, the diameter of the right ankle joint, the arthritic flexion pain test, and the content Glu in plasma by HPLC were all applied to be the indexes. Results X -ray and pathological section supported the establishment of chronic arthritic model in rat. Before treatment the diameter of the right ankle joint, scores of arthritic flexion pain test and the content Glu in plasma in experimental group were significantly higher than those in control group ( P 〈 0. 05 ) ; After 2 - week treatment the scores of arthritic flexion pain test and the content Glu in plasma in treated groups were significantly lower than those in on - treated group ( P 〈 0. 05 ) ; the diameter of the right ankle joint in lornoxicam group and ketamine and lornoxicam group were significantly lower than that in non - treated group ( P 〈 0. 05 ). The renascent cartilage cells were seen in pathological section in lornoxicam group and ketamine and lornoxicam group after 2 - week treatment. Conclusion Repeating injections of ketamine or lornoxicam in ankle joint cavity produced analgesia. Injection of lornoxicam in ankle joint cavity can diminish inflammation and accelerate joint recovery. Injection of optimal combination of ketamine and lornoxicam produced synergistic analgesia without significant aversive side effects.
出处 《昆明医学院学报》 2007年第4期84-87,共4页 Journal of Kunming Medical College
关键词 氯胺酮 氯诺昔康 关节炎 关节内注射 镇痛 Ketamine Lornoxicam Arthritis Intra - articular injections Analgesia.
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