摘要
采用邻溴苯酚为初始原料,在相转移催化剂作用下经烷基化合成2-(2-氯乙氧基)-1-溴苯(1),通过生成格氏试剂合成2,3-二氢苯并呋喃(2),由傅-克酰基化反应合成5-乙酰基-2,3-二氢苯并呋喃(3)。反应过程以薄层色谱法监控,并通过元素分析、1HNMR对各中间体的组成和结构进行了确证和表征。
Reaction of 2-bromophenol with 1,2-dichloroethane via alkylation in the presence of the phase transfer catalysis and sodium hydroxide afforded 1-bromo-2-（2-chloroethoxy）benzene （1）, and then reacted with magnesium and 1,2-dibromoethane in anhydrous tetrahydrofuran to produce 2,3-dihydrobenzofuran （2） followed by Friedel-crafts acetylation with acetyl chloride by using aluminum chloride as catalysis in dichloromethane to give 5-acetyl-2,3- dihydrobenzofuran （3）. The reaction process was monitored by TLC, and the compositions and structures of the intermediates were confirmed by means of elemental analysis and 1H NMR.
出处
《精细化工中间体》
CAS
2007年第4期34-35,62,共3页
Fine Chemical Intermediates
