摘要
目的L探讨肾素-血管紧张素-醛固酮系统(RAAS)在急性胰腺炎(AP)发生发展中的作用,为临床上对急性胰腺炎病情程度的判断和治疗提供依据。方法:对重症急性胰腺炎(SAP)、轻型急性胰腺炎(MAP)、急性胆囊炎(AC)、急性阑尾炎(AA)患者及正常对照(HC)组的血浆肾素活性(PRA)、血管紧张素-Ⅱ(AGT-Ⅱ)利用放射免疫法进行测定。结果:SAP急性期(SAP.A)PRA(4.2±1.9)ng/ml/h,AGT-Ⅱ(396.2±168.6)pg/ml;SAP恢复期(SAP.R)的PRA(1.42±0.72)ng/ml/h,AGT-Ⅱ(46.2±27.3)ng/ml,SAP.A与SAP.R比较,P〈0.05,二者比较差异有统计学意义。MAP急性期(MAEA)PRA为(1.8±0.9)ng/ml/h,AGT-Ⅱ(148.2±81.7)pg/ml;MAP恢复期(MAP.R)PRA为(1.1±0.6)ng/ml/h,AGT-Ⅱ(43.1±17.3)pg/ml,MAP.A与MAP.R比较P〈0.05,二者比较差异有统计学意义。HC的PRA为(O.66±0.43)ng/ml/h,AGT-Ⅱ(41.7±29.8)pg/ml,SAP.R、MAP.R与HC比较P〉0.05,二者比较差异无统计学意义。结论:AP恢复期的测定结果均较发病后24h内显著降低,与HC比较差异无统计学意义。且AP早期发病24h内PRA、AGT-Ⅱ显著增高,SAP较MAP升高明显。因此RAAS的恢复可以作为AP已不存在有效循环血量降低的指征。
Objective To assess the changes of plasma renin activity (PRA), angiotensin-Ⅱ (AGT-Ⅱ) and aldosterone (ALD) in patients with acute pancreatitis (AP). Methods Radioimmunoassay was utilized to determine the concentration of PRA and AGT-Ⅱ in patients with severe acute pancreatitis (SPA), mild acute pancreatitis (MAP), acute cholecystitis (AC), acute appendicitis (AA) and in healthy controls (HC). Results The mean concentration of plasma PRA and AGT-Ⅱ was (4.2±1. 9) ng · ml^-1· h^-1 and (396. 2±168. 6) pg · ml^-1 respectively in SAP acute phase group (A group), 1.42±0.72 ng · ml^-1· h^ 1 and (46.2±27.3) pg · ml^-1 respectively in SAP recovery phase group (R group). There was significant difference of PRA and AGT-Ⅱ between A group and R group (P〈0.05). The level of PRA and AGT-Ⅱ was (1.8±0.9) ng · ml^-1 · h^-1 and (48.2 ±81.7)pg · ml^-1 respectively in MAP acute phase group, (1.14±0. 6)ng ml^-1 · h^- 1 and (43.1±17. 3) pg · ml^-1 respectively in MAP recovery phase group. There was significant difference of PRA and AGT- Ⅱ between MAP acute phase group and MAP recovery phase group (P〈0.05). The mean concentration of PRA and AGT-Ⅱ was (0.66±0.43) ng · ml^-1· h^-1 and (41.7±29.8)pg · ml^-1 respectively in HC group. There was no significant difference of PRA and AGT- Ⅱ among SAP recovery phase group, MAP recovery phase group and HC group (P〉0.05). Conclusion The determined result in AP recovery phase is significant lower than that within 24 h after onset. There is no statistical difference between AP recovery phase group and healthy control group. The levels of PRA and AGT- Ⅱ increase markedly in the early phase (within 24 h after onset) of AP, especially in SAP. Thus, recovery of PRA and AGT-Ⅱ may be used as a marker of available circulation volume recuperation.
出处
《国际检验医学杂志》
CAS
2007年第8期684-685,共2页
International Journal of Laboratory Medicine